<em>Veratrilla baillonii</em>&amp;nbsp;Franch&amp;nbsp;alleviate the symptoms of diabetes in type 2 diabetic rats&amp;nbsp;induced by high-fat diet and streptozotocin

Our previous research studies have shown that&nbsp;Veratrilla baillonii&nbsp;Franch (V. baillonii), a food supplement used by ethnic minorities in Southwest China, has&nbsp;multiple&nbsp;pharmacological activities,&nbsp;such as detoxification, anti-inflammatory, antioxidant, and anti-insulin resistance.&nbsp;However,&nbsp;the detailed signal pathways&nbsp;for&nbsp;its salutary&nbsp;effect on damages multiple organs due to type 2 diabetes mellitus (T2DM)&nbsp;remains&nbsp;unclear. The current study is evaluate&nbsp;the&nbsp;therapeutic effects of V. baillonii T2DM rats explore the underlying mechanisms. The&nbsp;T2DM rat model was successfully established high-sugar high-fat diet (HFD) combination&nbsp;with intraperitoneal injection small dose streptozotocin (STZ, 35 mg/kg). Biochemical analysis histopatholgical examinations were conducted evaluate&nbsp;the anti-diabetic potential water extracts V. baillonii&nbsp;(WVBF). results&nbsp;showed&nbsp;that WVBF treatment can improve&nbsp;hyperglycemia&nbsp;and insulin resistance, ameliorate&nbsp;the&nbsp;liver, kidney pancreas&nbsp;injuries via decreasing&nbsp;inflammatory cytokines such IL-6 TNF-α, oxidative damages. Further investigation suggested that modulates transductions IRS1/PI3K/AKT/GLUT4 AMPK&nbsp;pathways. These findings demonstrate potentials&nbsp;of&nbsp;WVBF of&nbsp;T2DM&nbsp;and possible mechanisms&nbsp;for its hepatoprotective activities.